4(3H)-Pyrimidinone, 2,6-diamino-5-chloro-
2,6-Diamino-5-chloropyrimidin-4-ol
CAS: 71552-22-2
Molecular Formula: C4H5ClN4O
4(3H)-Pyrimidinone, 2,6-diamino-5-chloro- - Names and Identifiers
| Name | 2,6-Diamino-5-chloropyrimidin-4-ol |
| Synonyms | 2,6-Diamino-5-chloropyrimidin-4-ol 4(3H)-Pyrimidinone, 2,6-diamino-5-chloro- |
| CAS | 71552-22-2 |
4(3H)-Pyrimidinone, 2,6-diamino-5-chloro- - Physico-chemical Properties
| Molecular Formula | C4H5ClN4O |
| Molar Mass | 160.56 |
| Storage Condition | 2-8℃ |
| Sensitive | IRRITANT |
| MDL | MFCD22196157 |
4(3H)-Pyrimidinone, 2,6-diamino-5-chloro- - Introduction
2,6-Diamino-5-chloropyrimidin-4-ol (2, pyridinium) is an organic compound with the chemical formula C4H5ClN4O. It is a white crystalline solid that is sparingly soluble in water but has increased solubility under acidic conditions.
2,6-diamino-5-chloropyrimidin-4-ol has a wide range of applications in the field of medicine. It is an intermediate in many drugs, especially those against cancer. The compounds can be used in the synthesis of antineoplastic drugs such as certain alkalinizing agents and antimetabolites. In addition, it can be used in the synthesis of other organic compounds, including pesticides and dyes.
A method for preparing 2,6-diamino-5-chloropyrimidin-4-ol is the reaction of pentaamino 3-chloropyridine and ammonia. First, the penta amino 3-chloropyridine is dissolved in ethanol, a small amount of sodium hydroxide is added, and then ammonia water is added, and the mixture is heated while stirring. After the reaction, the product is treated with dilute acid and purified by filtration and crystallization to obtain the desired product.
Regarding safety information, 2,6-diamino -5-chloropyrimidine -4-ol is a general compound and does not pose a major safety risk during general use. However, as with all chemicals, proper handling and use should be observed, and appropriate protective measures (such as wearing gloves and protective glasses) should be taken to avoid contact with skin and eyes. Store in a sealed container and away from ignition and reactive substances. Avoid dust during use to avoid inhalation or contact with mucous membranes. If contact or inhalation occurs, rinse immediately with plenty of water and seek medical help.
2,6-diamino-5-chloropyrimidin-4-ol has a wide range of applications in the field of medicine. It is an intermediate in many drugs, especially those against cancer. The compounds can be used in the synthesis of antineoplastic drugs such as certain alkalinizing agents and antimetabolites. In addition, it can be used in the synthesis of other organic compounds, including pesticides and dyes.
A method for preparing 2,6-diamino-5-chloropyrimidin-4-ol is the reaction of pentaamino 3-chloropyridine and ammonia. First, the penta amino 3-chloropyridine is dissolved in ethanol, a small amount of sodium hydroxide is added, and then ammonia water is added, and the mixture is heated while stirring. After the reaction, the product is treated with dilute acid and purified by filtration and crystallization to obtain the desired product.
Regarding safety information, 2,6-diamino -5-chloropyrimidine -4-ol is a general compound and does not pose a major safety risk during general use. However, as with all chemicals, proper handling and use should be observed, and appropriate protective measures (such as wearing gloves and protective glasses) should be taken to avoid contact with skin and eyes. Store in a sealed container and away from ignition and reactive substances. Avoid dust during use to avoid inhalation or contact with mucous membranes. If contact or inhalation occurs, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 20:52:54
